What's so special with this video? MotionPortrait claims that it was created from a single picture! They have not yet realeased any software but by searching the internet I found CrazyTalk, which is a program that does exactly the same, Facial Animation & Lip-sync.
In other words you feed the program with a single 2D picture and you can animate it. You can even make it talk (either with Text-to-Speech or even with a wav file). You must try it to believe it.
Similar Technology: http://www.motionportrait.com/e/